Journal Club 1

Presented by Hayley (Steif Lab)

Title: Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

Authors: Pilar Baldominos, et al.

Journal: Cell

Year: 2022

Highlights:

• Antigen-expressing tumor cells that escape from T cell attack are quiescent.
• Quiescent cancer cells (QCCs) form clusters that exclude immune infiltrates.
• PADME-seq reveals an increase in terminally exhausted T cells in the QCC niche.
• HIF1a activation in cancer cells augments T cell exhaustion and reduces T cell killing.